Mats nilsson

The landscape of tumor fängelse states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location

Ilon Liu, Li Jiang, Erik R Samuelsson, Sergio Marco Salas, A. Beck, Olivia A Hack, Daeun Jeong, McKenzie L Shaw, B. Englinger, Jenna LaBelle, Hafsa M Mire, S. Madlener, Lisa Mayr, Michael A Quezada, Maria C Trissal, E. Panditharatna, K. Ernst, Jayne Vogelzang, Taylor A. Gatesman, Matthew E. Halbert, Hana Pálová, P. Pokorná, J. Štěrba, O. Slabý, R. Geyeregger, A. Diaz, Izac J. Findlay, M. Dun, A. Resnick, M. Suvà, David C. Jones, S. Agnihotri, J. Svedlund, C. Koschmann, C. Haberler, T. Czech, inom. Slavc, J. Cotter, K. Ligon, S. Alexandrescu, W. Yung, inom. Arrillaga-Romany, J. Gojo, M. Monje, M. Nilsson, Mariella G. Filbin

natur Genetics,

Our laboratory lies at the intersection between technical innovation and scientific exploration.

We focus on the development, refinement, and application of cutting-edge methods for in-situ transcriptomics, to unravel the complexities of gene expression within cells and tissues in their native environments.

Our lab has made significant contributions to the field of in situ sequencing, generating powerful tools for high-throughput and highly multiplexed analysis of mRNA.

A cornerstone of our research lies in the use of padlock probes, a versatile and robust technology that forms the foundation of our diverse range of projects. By harnessing the versatility of this molecular tool,  we are able to extract massive amounts of gene expression data from tissues, so to gain insight about various biological processes.

We currently work mainly in the following directions:

Spatially Resolved Transcriptomics: 
We develop innovative methods to visualize and analyze gene expression patterns within intact tissues. By elucidating the spatial context of gene expression, we gain a deeper understanding of tissue biology in a variety of model systems. In humans we explore both hea

Prof Mats Nilsson

Professor of Biochemistry at Stockholm University and Associate Faculty at the Sanger Institute

My research seeks to understand how cells develop and behave within the organs of the body in health and disease. Specifically I seek to understand how cells work together to maintain healthy tissues and how this changes in cancer or in response to an infection. I and my team develop cutting-edge molecular and computational techniques to measure the activity of genes within individual cells (in-situ sequencing) in an intact tissue and map these cells' relative positions (spatial biology). Our goal is to produce insights that guide future diagnostics and treatments.

I am convinced that the next wave of biological discovery and application is spatial biology. The goal of modern cell biology is to precisely understand (and then improve or enhance) how our organs behave in health and disease.

Incredible strides forward in single-cell research have been made to generate molecular profiles individual cells within a tissue. The genetic, genomic and transcriptomic data being generated at scale is helping to unlock fresh insights into the makeup and developm